克里斯托弗·弗莱博士
Alcohol and Dysfunctional Skeletal Muscle Mass: Implications in Aging
路易斯安那州立大学
这个项目将重点放在设计上, 解释, and analysis of experimental data from muscle stems cells to facilitate skeletal muscle extracellular matrix (ECM) remodeling. There will also be analyzing of the human primary cell culture and matrisome turnover. This combination will enable the definition of the effects of alcohol use on dysregulated ECM turnover and myogenic capacity in older adults.
履约时间:2023年9月至2025年8月
总价值:12962美元

Esther Dupont-Versteegden博士
Muscle and Physical Function Recovery after Acute Respiratory Failure
NIAMS,美国
The overall goal of this clinical observational study is to determine cellular processes of the underlying failure to recover muscle function and understand the relationships between the presence of dysfunctional cellular mechanisms with physical dysfunction in survivors of critical illness.
履约时间:2023年9月至2028年8月
奖:2249868美元

克里斯托弗·弗莱博士
Preserving Physical Function in Patients with Kidney Disease
爱因斯坦医学院
This study will define specific cellular adaptations underlying the skeletal muscle pathology in patients with chronic kidney disease. Identification of these biologic mechanisms is needed to delineate the etiology of skeletal muscle pathophysiology and identify novel therapeutic targets that can be pursued in future studies.
履约时间:2021年8月至2026年6月
总价值:479,524美元

克里斯托弗·弗莱博士
Myostatin Alters Muscle Composition as the Result of an ACL Injury
国立关节炎肌肉骨骼研究所 & 皮肤病
This study is to determine the time course of deleterious changes within the injured limb muscle and identify myostatin as integral in the etiology of protracted muscle weakness in individuals following an ACL tear and reconstruction.
履约时间:2018年3月至2024年2月
总价值:1,858,598美元

克里斯托弗·弗莱博士
Rejuvenation of Skeletal Muscle Regeneration in Patients with Kidney Disease
爱因斯坦医学院
This study will define specific cellular adaptations underlying the skeletal muscle pathology in patients with chronic kidney disease. Identification of these biologic mechanisms is needed to delineate the etiology of skeletal muscle pathophysiology and identify novel therapeutic targets that can be pursued in future studies.
执行期限:2023年1月至2023年12月
总价值:3万美元

克里斯托弗·弗莱博士 & 斯坦利·沃托维奇博士
Preclinical Developments of a Novel Therapeutic to Rejuvenate Aging Muscle Stem
山脊线疗法
This Phase II project will streamline efforts to develop an oral drug for hip fracture recovery. The therapeutics we are developing to improve muscle recovery and physical function will greatly enhance the quality of life of millions of older Americans at a high risk for fall-related injuries and dramatically reduce the financial burden on the US healthcare system.
履约时间:2021年9月至2024年8月
总价值:353,863美元

夏洛特·彼得森博士, and John McCarthy, PhD (College of Medicine)
The Role of Satellite Cells in Skeletal Muscle Hypertrophy with Aging
国家老龄研究所
The purpose of this five-year study is to better understand the role of skeletal muscle stem cells (satellite cells) in the blunted growth response to exercise in the elderly, thereby providing a foundation for the potential use of stem cell therapy to prevent or restore losses in skeletal muscle mass during aging.
履约时间:2021年8月至2026年4月
总价值:1,794,362美元

夏洛特·彼得森博士 and John McCarthy, PhD (College of Medicine)
Exercise-induced Skeletal Muscle Exosomes Promote Adipocyte Lipolysis
美国国家糖尿病研究所 & 消化 & 肾脏疾病
This study investigates the mechanism through which resistance exercise causes skeletal muscle to communicate with adipose tissue to promote the burning of fat. The findings from this study are expected to provide the fundamental knowledge necessary to develop a novel therapeutic strategy to treat obesity using exosomal miR-1 delivery to adipose tissue.
履行期限:2018年9月至2024年7月
总价值:1,945,714美元

夏洛特·彼得森博士, and John McCarthy, PhD (College of Medicine)
肠道微生物群在肌肉减少症中的作用
国家老龄研究所
The purpose of this exploratory grant is to test the hypothesis that dysbiosis of the gut microbiota promotes sarcopenia by inducing a state of anabolic resistance in skeletal muscle through TLR4 hyperactivation of mTORC1 signaling.
履约时间:2021年5月至2024年1月
总价值:406,220美元

夏洛特·彼得森博士
Novel Gastrocnemius Muscle Characteristics in Peripheral Artery Disease Patients
国家老龄研究所
The goal of this study is to identify aberrant properties of muscle to aide in the development of new targeted interventions to improve walking ability in individuals with PAD.
履约时间:2021年1月至2025年12月
总价值:1,573,904美元

夏洛特·彼得森博士
Intermittent Pneumatic Compression for Disability Reversal in PAD: The INTERCEDE Study
Northwestern University (国家老龄研究所)
外周动脉疾病患者, we will determine whether treatment with intermittent pneumatic compressive augments the benefits of exercise, whether intermittent pneumatic compression alone improves walking performance compared to control, and whether the benefits of intermittent pneumatic compression are durable.
履约时间:2018年8月至2024年4月
总价值:122,881美元

柯比·梅尔，DPT，博士
细胞 & Physical Function Outcomes Leading to Failed Muscle Recovery After Critical Illness
国立卫生研究院
This study will focus on skeletal muscle protein turnover, 细胞信号通路, and TNA and mitochondrial biogenesis after critical illness. The findings will determine factors associated with the failure to recover muscle and understand the relationship with physical function in survivors of critical illness.
演出时间:2022年8月至2027年7月
总价值:745,178美元